Approximately how many polymorphisms can be found in the human genome?

Prepare for the ASCP Molecular Biology (MB) Technologist Exam. Study with flashcards and multiple-choice questions, each with hints and explanations. Get ready to succeed!

The correct answer is that approximately 10 million polymorphisms can be found in the human genome. Polymorphisms refer to variations in the DNA sequence among individuals, which can be single-nucleotide polymorphisms (SNPs), insertions, deletions, or other types of variations. Research has shown that the human genome contains a vast number of SNPs, with estimates indicating there are around 10 million or more. This diversity is a key aspect of human genetics and contributes to Differences in phenotype, susceptibility to diseases, and response to medications.

In understanding the full scope of genetic variability in the human population, it's essential to recognize that these polymorphisms occur in both coding and non-coding regions of the genome. Their abundance relates to the complex history of human evolution and the ongoing mutation processes that drive genetic diversity.

The other options reflect lower estimates than what current genomic studies suggest for the total number of polymorphisms. While the human genome does contain closer to 10 million polymorphic sites, the estimates of only 100,000 or 1 million significantly underestimate the true genetic variation present in the population. The option of approximately 50 million also exceeds the current understanding of polymorphism frequencies as more research continues to refine these numbers

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