What gene is measured following treatment with Warfarin?

The measurement of the VKORC1 gene following treatment with Warfarin is crucial because this gene encodes the enzyme vitamin K epoxide reductase, which is the target of Warfarin's anticoagulant effect. Variations in the VKORC1 gene significantly influence an individual's response to Warfarin, affecting the dose required to achieve therapeutic anticoagulation. Polymorphisms in this gene can lead to differences in Warfarin metabolism, resulting in varying sensitivity to the drug.

This is particularly important for personalizing Warfarin therapy to reduce the risk of bleeding complications or inadequate anticoagulation. Genetic testing for VKORC1, along with other genes such as CYP2C9, helps clinicians determine the most effective and safe Warfarin dose for individual patients. The relevance of VKORC1 in this context underscores its significance in pharmacogenomics and personalized medicine.