What is one characteristic of random priming in DNA particularly advantageous for hybridization?

Random priming is a technique used in molecular biology to generate labeled probes for hybridization, and one of its significant advantages is that it increases the binding sites of probes. This characteristic stems from the fact that random priming allows for the generation of a diverse array of DNA fragments, which means that multiple different sequences can be synthesized from a single template. By using random primers that can bind to various regions of the template DNA, a larger number of unique binding sites are created. This versatility enhances the likelihood that the probes will hybridize successfully with complementary sequences in the target DNA or RNA during assays such as in situ hybridization or various forms of PCR.

This increased diversity of binding sites effectively broadens the potential applications of the labeled probes and improves the sensitivity and specificity of detection in hybridization assays.