What is the disease associated with the translocation t(8;14)?

The translocation t(8;14) is specifically associated with Burkitt's lymphoma, which is a type of non-Hodgkin lymphoma characterized by a high proliferation rate of B-cells. This genetic abnormality involves the MYC oncogene on chromosome 8 moving to chromosome 14, where it juxtaposes to the immunoglobulin heavy chain locus. This translocation leads to the overexpression of the MYC gene, significantly contributing to the pathogenesis of Burkitt's lymphoma by driving uncontrolled cell proliferation.

Burkitt's lymphoma is most commonly seen in children and is known for its association with specific clinical and geographic variants. In particular, the endemic form, often associated with malaria, primarily occurs in African children and is characterized by facial swelling due to jaw lesions. The sporadic form may appear in adults and often presents as an abdominal mass.

The incorrect options are associated with other types of lymphoproliferative disorders but do not involve the t(8;14) translocation. Hodgkin's lymphoma has distinct genetic and clinical features and is characterized by the presence of Reed-Sternberg cells. Non-Hodgkin's lymphoma is a broad category that includes various types of lymphomas, while acute lymphoblastic