What is the function of DNA Polymerase δ in eukaryotes?

DNA Polymerase δ plays a crucial role in both DNA replication and repair processes in eukaryotes. During DNA replication, it is primarily responsible for synthesizing the lagging strand. This polymerase has a proofreading ability, which means it can correct errors that occur during DNA synthesis, ensuring high fidelity in the replication process.

The proofreading capability stems from its intrinsic 3’ to 5’ exonuclease activity, allowing it to remove incorrectly incorporated nucleotides and replace them with the correct ones. This quality control mechanism is essential for maintaining genetic stability and preventing mutations.

In contrast, other options reflect functions that are either incomplete or incorrectly attributed to DNA Polymerase δ. While DNA repair is an important function, stating that it only repairs DNA is too narrow and excludes its vital role in replication. Additionally, DNA Polymerase δ does not possess primase activity, which is instead the function of separate polymerases in the replication process. Lastly, its contribution is not limited to just the lagging strand; it is also involved in the overall replication process beyond that sole function.