What is the primary function of eukaryotic DNA Polymerase ε?

Eukaryotic DNA Polymerase ε plays a critical role in the replication of DNA, primarily focusing on the leading strand. During DNA replication, the leading strand is synthesized in a continuous manner, as opposed to the lagging strand, which is synthesized in discontinuous fragments known as Okazaki fragments. DNA Polymerase ε is specifically responsible for this continuous synthesis as it has a high processivity and is essential for accurately and efficiently elongating the leading strand.

In addition to its primary role in leading strand replication, DNA Polymerase ε is also involved in the repair mechanisms of DNA, contributing to the overall integrity of the genetic material. This dual functionality emphasizes its importance in maintaining both the replication process and the response to DNA damage.

Understanding the specific activities of different polymerases, including DNA Polymerase ε, allows for a more profound insight into eukaryotic cellular processes related to DNA replication and repair mechanisms.