What type of malignancy is associated with T-Cell Gene Rearrangement?

T-cell gene rearrangement is primarily associated with malignancies that involve T lymphocytes, which are a type of white blood cell involved in the immune response. Non-Hodgkin Lymphoma (NHL) is a broad category of lymphomas that includes many types of lymphoid malignancies, and some of these specifically exhibit T-cell gene rearrangement due to the neoplastic transformation of T-cells.

In particular, T-cell Non-Hodgkin Lymphomas, such as peripheral T-cell lymphoma and others, often present with T-cell receptor (TCR) gene rearrangements. This genetic alteration helps in the diagnosis and classification of the type of lymphoma. Therefore, when considering malignancies associated with T-cell gene rearrangement, Non-Hodgkin Lymphoma represents a key category where such genetic events are observed.

While Sézary syndrome, a leukemic form of cutaneous T-cell lymphoma, does involve T-cell gene rearrangement, it is actually a more specific subset of T-cell malignancies. Burkitt's lymphoma and Acute lymphoblastic leukemia are primarily associated with B-cell malignancies and do not typically feature T-cell gene rearrangement. Thus, Non-Hodgkin Lymphoma serves as the most suitable