Which chromosomal position is commonly affected in β-thalassemia?

The chromosomal position that is commonly affected in β-thalassemia is located on chromosome 11. This condition arises primarily due to mutations in the HBB gene, which is situated on chromosome 11, specifically at the beta-globin cluster. These mutations can lead to reduced or absent production of beta-globin, a crucial component of hemoglobin, resulting in the characteristic symptoms of β-thalassemia, such as anemia and related health issues.

The significance of this chromosomal location is particularly relevant in understanding the genetics and molecular basis of β-thalassemia. It's important for genetic counseling, screening, and potential therapeutic approaches aimed at correcting the underlying genetic defect. The mutations on chromosome 11 can vary widely, and the severity of the disease often correlates with the type of mutation present.

In contrast, while chromosomes 13, 16, and 7 may also contain genes related to other forms of thalassemia or different types of hemoglobinopathies, they are not primarily associated with β-thalassemia itself. Thus, chromosome 11 is conclusively linked to this specific disorder.