Which gene mutation is NOT associated with Hemochromatosis?

Hemochromatosis is a genetic disorder primarily associated with excessive iron absorption in the body, commonly linked to mutations in the HFE gene. The C282Y and H63D mutations are well-documented variants of the HFE gene that contribute to the development of hereditary hemochromatosis. The S65C mutation is also associated with hemochromatosis, albeit less frequently than the C282Y and H63D mutations.

On the other hand, BRCA1 is a gene primarily associated with breast and ovarian cancers. Mutations in BRCA1 significantly increase the risk of developing these types of cancers but do not have any direct connection to iron metabolism or hemochromatosis. This distinction clearly indicates why BRCA1 is not associated with the disorder, making it the correct answer to the question. Understanding the different functions and implications of these genes is essential for differentiating conditions associated with specific mutations.