Which molecule is primarily bound by labeled monoclonal antibodies in hybrid capture?

In hybrid capture methods, labeled monoclonal antibodies are primarily used to bind to RNA targets. This technique is designed to specifically capture nucleic acids, particularly RNA, through the use of antibodies that recognize specific sequences or structures in the RNA molecules. This is particularly useful in applications like detecting and quantifying viral RNA or mRNA, allowing for the study of gene expression and the identification of pathogens.

Monoclonal antibodies are carefully selected to have high specificity for their targets, which ensures that the hybrid capture process can efficiently isolate the desired RNA from a complex mixture. This quality makes it a powerful tool in molecular biology research and diagnostic applications.

Other options such as disease biomarkers, DNA templates, and protein markers are not the primary focus of hybrid capture as it pertains to the use of labeled monoclonal antibodies in this context. While these molecules can have their own methods of detection and analysis, they do not represent the main targets for hybrid capture when employing monoclonal antibodies specifically designed for RNA interactions.