Which of the following oncogenes have tyrosine kinase activity?

The correct answer is that all of the mentioned oncogenes exhibit tyrosine kinase activity.

Tyrosine kinases are crucial players in cellular signaling pathways, particularly those related to growth and differentiation. Each of the oncogenes listed is known for its role in cancer through mechanisms involving tyrosine kinase activity.

EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that, when activated by binding to its ligand, undergoes autophosphorylation. This phosphorylation activates several downstream signaling pathways that promote cell proliferation and survival, connecting it to various cancers.

BCR-Abl is a fusion protein resulting from the Philadelphia chromosome translocation associated with chronic myeloid leukemia (CML). This fusion combines the breakpoint cluster region (BCR) gene with the Abelson murine leukemia viral oncogene (Abl), creating a constitutively active tyrosine kinase that leads to uncontrolled cell division.

HER2 (human epidermal growth factor receptor 2) is another receptor tyrosine kinase that, when overexpressed, is implicated in breast cancer. Like EGFR, HER2 can trigger signaling cascades promoting cell division and survival through its tyrosine kinase activity.

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